Analysis of a COVID-19 Vaccinated Patient (Pre&Postmortem)

Effective immunity & Sterile immunity of Pfizer-BioNTech mRNA COVID-19 vaccine.

German researchers reported a postmortem analysis of a 86 years old man, whom had been vaccineted with Pfizer-BioNTech mRNA COVID-19 vaccine 24 days before. The man already had had hypertension, chronic venous insufficiency, dementia, prostate carcinoma before he took the vaccine. Fifteen days after the vaccination, he collapsed during his breakfast.

The following symptoms were NOT FOUND before the vaccination:

A. Eighteen days after the vaccination (day 18), he was rushed to the hospital because of worsening diarrhoea, C- reactive protein 1.0 mg/dl (inflammation marker, normal <0.5 mg/dl).

With negative result tested for SARS-CoV-2, laboratory tests showed he had hypochromic anemia (day 19) and increased creatinine serum (day 18).

By colonoscopy (day 20), it was shown that there was ulcerative lesion and he was diagnosed with Ischemic Colitis (IC). He was given Mesalazine and intravenous iron substitution. Then he had renal insufficiency.

B. On day 20, he was tested negative for SARS-CoV-2.

C. On the 25th day after the vaccination, he was tested positive for SARS-CoV-2, the transmission was from another patient in the same room (tested positive for SARS-CoV-2 on the 24th day of our 86 years old man). The 86 years old man was given Ceftriaxone (antibiotic). The next day (26th day) he died because of acute renal failure and bronchopneumonia. Only olfactory bulb and liver were not affected by SARS-CoV-2, in postmortem analysis. This showed the early stage of infection.

Ischemic Colitis (IC) is an inflammatory condition of the large intestine (colon). Artherosclerosis (plaque i.e. fatty deposits, inside the arteries) can cause chronic and long term IC, yet was not found in the 86 years old man. Blood clot can cause sudden IC, also wasn't found before. No history of coronary artery disease or peripheral vascular disease, no irregular heartbeat too. Though colon cancer also shows ulcerated lesions, the paper did not state any cancer in him.

Mesalazine is a medication for Inflammatory Bowel Disease (IBD), ulcerative colitis, and Chron's disease. Iron was given because of the hypochromic anemia. Hypochromic anemia is the pale RBC (red blood cell) condition. It showed the iron deficiency after the vaccination. Not presented before vaccination.

Usually, inflammation (colon) will rise the Hepcidin, a key regulator of the entry of iron into mammals circulation, this will increase the iron in the tissues but low iron absorption in the RBC. The low iron absorption in the blood will turn the RBC into pale redness. The Hemoglobin was below 14 g/dl from day 180 until day 26.

The C-reactive protein on day 18 was 1.0 mg/dl, on day 23 was 2.0 mg/dl, and on day 26 was 8.8 mg/dl. The normal C - reactive protein is <0.5 mg/dl. Thus, these show the inflammation had happened before the 25th day.

Creatinine serum was

1.91 mg/dl (day 18),

1.78 mg/dl (day 19),

2.04 mg/dl (day 23),

2.17 mg/dl (day 25), and

3.23 mg/dl (day 26).

Normal range is 0.7-1.2 mg/dl. Thus, the kidney already had problem before day 25th.

Postmortem study revealed:

- acute bilateral bronchopneumonia with abscesses, sometimes being surrounded by bacterial cocci

- biventricular hypertrophy in the heart (weight 580 g) and histologically, thus ischemic cardiomyopathy

- amyloidosis of the transthyretin type in the heart and to a lesser extent in the lungs

- kidneys revealed both chronic damage with arteriolosclerosis and interstitial fibrosis, and acute renal failure with hydropic tubular degeneration

- a left parietal pseudocystic tissue necrosis, which was diagnosed as an old infarction area.

Before tested positive for SARS-CoV-2, the 86 years old man had already had inflammation, but not before the vaccination. His IgG showed the presence of antibody because of the vaccine.

The inflammation before the 25th day, was more likely because of the Spike proteins. Petruk et.al. reported that Spike proteins alone are toxic in certain concentration. It was observed that SARS-CoV-2 S protein alone did not induced significant increase in NF-κB/AP-1 activation at the concentration of 10 nM, without LPS (lipid polysaccharide). If with LPS (2.5 ng/ml) and S protein 5 nM, there's a significant increase in NF-κB/AP-1 (pro-inflammation).

Effective immunity of Pfizer-BioNTech mRNA vaccine was shown from Spike protein antigen-binding IgG in the serum sample obtained at 25th day, 8.7 U/ml, reference value <0.8-1.2 U/ml. Nucleocapsid NCP-IgG/IgM was not elicited. Effective immunity is the development of antibodies to prevent infection.

Nevertheless, sterile immunity was not achieved by Pfizer-BioNTech mRNA vaccine. Sterile immunity is the type of immunity that completely prevents a disease. The presence of inflammation before tested positive for SARS-CoV-2, showed that the vaccine itself had brought adverse effects. The hypochromic anemia was present before day 24, which means the vaccine itself can cause anemia, in accordance with the report of the vaccine trials (low number). The C-reactive protein also showed the inflammation before day 24, the SARS-CoV-2 transmission day. Thus, the vaccine itself had caused anemia and renal inflammation.


Sources:

https://www.ijidonline.com/article/S1201-9712(21)00364-7/fulltext

https://academic.oup.com/jmcb/article/12/12/916/6028992