Considering (Auto)Immune Deficiency
Children Acute Autoimmune Hepatitis, A Generation Tragedy
The tragic news of acute autoimmune hepatitis (AIH) in children lately is alarming as it happened in many parts of this world; from Europe to Asia as per this article is written. According to WHO1, “As of 21 April 2022, at least 169 cases of acute hepatitis of unknown origin have been reported from 11 countries in the WHO European Region and one country in the WHO Region of the Americas (Figure 1). Cases have been reported in the United Kingdom of Great Britain and Northern Ireland (the United Kingdom) (114), Spain (13), Israel (12), the United States of America (9), Denmark (6), Ireland (<5), The Netherlands (4), Italy (4), Norway (2), France (2), Romania (1), and Belgium (1).”
Strait Times2 reported that based on investigations so far, the three fatal cases in Indonesia showed no history of hepatitis or jaundice, or displayed similar hepatitis symptoms after the children were affected, neither their families, according to the ministry of health. Singapore reported a case of acute hepatitis in a 10-month-old baby.
Adenovirus, SARS-CoV-2, hepatitis A to E virus, or history of hepatitis, are hypothesized in those cases. There is no hepatitis virus antigen in all of them. Some had adenovirus 41, some had SARS-CoV-2, some had the coinfection of both. With these early differences, it is unlikely to blame those viruses. Those cases have elevated liver enzymes; aspartate transaminase (AST) or alanine aminotransaminase (ALT) are greater the 500 IU/L.
Vergani3 et. al, wrote that in order AIH to occur, an unknown but powerful stimulus must be promoting the formation of this massive inflammatory cellular reaction that is likely to initiate and perpetuate liver damage. In 2004, Lapierre4 et. al published a paper about a murine model of AIH can be generated by DNA immunization against type 2 AIH self-antigens. A plasmid from mouse and the antigenic region of human and human enzyme was used for DNA immunization of female mice. Immunized mice showed elevated levels of ALT, with peaks at 4 and 7 months postinjection. Another model with the control mice & adenovirus, did not show the reminiscent of AIH. Likely, adenovirus alone cannot be the cause of recent AIH.
WHO stated that, “Hypotheses related to side effects from the COVID-19 vaccines are currently not supported as the vast majority of affected children did not receive COVID-19 vaccination.” In adult groups, the sudden AIH cases after COVID-19 vaccines can be read in many scientific publications recently. Though there is still no scientific research that link those children AIH and COVID-19 vaccines, recent publication5 about aerosol transfer of SARS-CoV2-specific humoral immunity emerges the possibility of COVID-19 vaccine shedding. Does the mass vaccination of COVID-19 vaccine contribute to the recent AIH in children? If it does, which vaccine generates the most aerosol-transferable antigens? And the mandated vaccine should be stopped. Household environments are uncontrolled variables; thus, we do not see that every child gets the AIH. When the late Prof Montagnier mentioned the mRNA COVID-19 vaccine will make many people get AIDS (not HIV), could recent AIH be the one of the immune deficiencies that this great scientist referred to?
https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON376
https://www.straitstimes.com/asia/se-asia/indonesia-reports-more-suspected-cases-of-acute-hepatitis-among-children
https://pubmed.ncbi.nlm.nih.gov/18528928/
https://pubmed.ncbi.nlm.nih.gov/15057911/
https://www.medrxiv.org/content/10.1101/2022.04.28.22274443v1.full.pdf